D-(-)-PANTOLACTONE

Product Name: D-(-)-PANTOLACTONE
CAS No.: 599-04-2
Chemical Name: D-(-)-PANTOLACTONE
Synonyms: PANTOLACTONE;D-PANTOLACTONE;(R)-3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one;Pantoyl lactone;Pantoyllactone;(R)-(-)-PANTOLACTONE;Dexpanthenol Lactone IMpurity;(3R)-3-hydroxy-4,4-dimethyloxolan-2-one;2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, (R)-;Pantolacton
CBNumber: CB3748921
Molecular Formula: C6H10O3
Formula Weight: 130.14
MOL File: 599-04-2.mol

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D-(-)-PANTOLACTONE Property

Melting point:: 91 °C(lit.)
Boiling point:: 120-122 °C15 mm Hg(lit.)
Density: 1.1066 (rough estimate)
vapor pressure: 0.3-3.28Pa at 15-35℃
refractive index: -50.8 ° (C=2, H2O)
Flash point:: 120-122°C/15mm
storage temp.: 2-8°C
solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Sparingly)
pka: 13.12±0.40(Predicted)
form: Crystals or Crystalline Powder
color: White
Odor: cotton candy
optical activity: [α]25/D 49.8°, c = 2 in H2O
Water Solubility: almost transparency
Sensitive: Hygroscopic
Merck: 14,7013
BRN: 80957
InChIKey: SERHXTVXHNVDKA-BYPYZUCNSA-N
LogP: -0.973--0.46 at 22.5-25℃ and pH7.1
CAS DataBase Reference: 599-04-2(CAS DataBase Reference)
EPA Substance Registry System: Pantolactone (599-04-2)

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Safety

Safety Statements: 22-24/25
WGK Germany: 1
F: 3-10
TSCA: Yes
HS Code: 29322090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 237817
Product name: D-(?)-Pantolactone
Purity: 99%
Packaging: 5g
Price: $19.98
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1494807
Product name: Pantolactone
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 500mg
Price: $1310
Updated: 2024/03/01

TCI Chemical

Product number: P0011
Product name: D-(-)-Pantolactone
Purity: >98.0%(T)
Packaging: 25g
Price: $52
Updated: 2021/12/16

TCI Chemical

Product number: P0011
Product name: D-(-)-Pantolactone
Purity: >98.0%(T)
Packaging: 500g
Price: $469
Updated: 2022/04/27

Alfa Aesar

Product number: L15983
Product name: D-(-)-Pantolactone, 99%
Packaging: 5g
Price: $23.65
Updated: 2024/03/01

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D-(-)-PANTOLACTONE Chemical Properties,Usage,Production

Chemical Properties

WHITE CRYSTALLINE POWDER OR CRYSTALS

Uses

D-(-)-Pantolactone is a chiral auxiliary used in many asymmetric synthesis reactions.
It can be used as a chiral starting material to synthesize:

An insect sex pheromone named 1S,2S,3R-1-acetoxymethyl-2,3,4,4-tetrameth-ylcyclopentane.
(-)-Enantiomer of (R)-8-hydroxy-4,7,7-trimethyl-7,8-dihydrocyclopenta[e]isoindole-1,3(2H,6H)-dione, a norsesquiterpene alkaloid.
A bicyclic diterpene named isofregenedadiol.

Uses

D-(-)-PANTOLACTONE is an important intermediate in the synthesis of pantothenic acid as well as a degradation product of pantothneic acid in the liver. Causes disorientation and hypothermia, and prevents phenamine-induced hyperthermia.

Definition

ChEBI: (R)-pantolactone is a butan-4-olide that is dihydrofuran-2(3H)-one substituted by a hydroxy group at position 3 and two methyl groups at position 4 (the R-stereoisomer). It has a role as a Saccharomyces cerevisiae metabolite. It is functionally related to a (R)-pantoic acid.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Purification Methods

Recrystallise the lactone from Et2O/pet ether, diisopropyl ether or *C6H6/pet ether and sublime it at 25o/0.0001mm. It hydrolyses readily to the hydroxy-acid and racemises when heated above 145o. The Brucine salt has m 211-212o (from EtOH). [Kuhn & Wieland Chem Ber 73 1134 1940, and Stiller et al. J Am Chem Soc 62 1779 1940, Bental & Tishler J Am Chem Soc 68 1463 1946, Beilstein 18/1 V 22.]

D-(-)-PANTOLACTONE Preparation Products And Raw materials

Raw materials

Formaldehyde Sodium cyanide HYDROGEN CYANIDE Methanol Isobutyraldehyde Sulfuric acid

Preparation Products

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D-(-)-PANTOLACTONE Suppliers

Americas 1 Belgium 3 Canada 2 China 239 Europe 3 France 1 Germany 5 India 8 Japan 4 Poland 1 Switzerland 2 The Netherlands 2 Ukraine 1 United Kingdom 12 United States 42 Global 326

HBCChem, Inc.

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Alfa Chemistry

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Standardpharm Co. Ltd.

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Aladdin Scientific

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TargetMol Chemicals Inc.

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Aceschem Inc.

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View Lastest Price from D-(-)-PANTOLACTONE manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: D-(-)-PANTOLACTONE 599-04-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2023-09-13

XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD

Product: D-(-)-PANTOLACTONE 599-04-2
Price: US $25.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 5000KG/MONTH
Release date: 2022-01-20

Hebei Guanlang Biotechnology Co,.LTD

Product: D-(-)-Pantolactone 599-04-2
Price: US $15.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 1 ton
Release date: 2021-06-23

599-04-2, D-(-)-PANTOLACTONERelated Search:

H-BETA-ALA-BETA-ALA-OH (2S)-2,4-Dihydroxy-3,3-dimethylbutanoic acid (R)-Methyl 3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate Vitamin B5 Impurity 1 3,3-BIS(N,N-DIPROPANOIC ACID) DL-Pantolactone PICROTOXIN L-Pantolactone, (S)-(+)-β,β-Dimethyl-α-hydroxy-γ-butyrolactone,(S)-(+)-PANTOLACTONE,L-PANTOLACTONE ALPHA-HYDROXY-GAMMA-BUTYROLACTONE Bilobalide GINKGOLIDEM Ginkgolide A Ginkgolide J PICROTOXININ Ginkgolide B Ginkgolide C PICROTIN Gamma Butyrolactone

(R)-()-β,β-Dimethyl-α-hydroxy-γ-butyrolactone

(R)-(-)-DIHYDRO-3-HYDROXY-4,4-DIMETHYL-2(3H)-FURANONE

(R)-DIHYDRO-3-HYDROXY-4,4-DIMETHYL-2(3H)-FURANONE

(R)-(-)-BETA,BETA-DIMETHYL-ALPHA-HYDROXY-GAMMA-BUTYROLACTONE

(R)-(-)-PANTOLACTONE

(R)-(-)-ALPHA-HYDROXY-BETA,BETA-DIMETHYL-GAMMA-BUTYROLACTONE

R(-)-3,3-DIMETHYL-2-HYDROXY-GAMMA-BUTYROLACTONE

R(-)-2-HYDROXY-3,3-DIMETHYL-GAMMA-BUTYROLACTONE

PANTOIC ACID GAMMA-LACTONE

PANTOLACTONE

PANTOLACTONE-D

2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, (R)-

2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, D-(-)-

4-dimethyl-dihydro-3-hydroxy-(theta)-2(3h)-furanon

D-(-)-Pantoic acid lactone

D-(-)-Pantolyl lactone

dihydro-3-hydroxy-4,4-dimethyl-,(R)-2(3H)-Furanone

Dihydro-4,4-dimethyl-3-hydroxy-2(3H)-furanone

-Hydroxy-,-dimethyl-butyrolactone

Pantoiclactone

Pantolyl lactone

Pantothenic lactone

Pantoyl lactone

Pantoyllactone

Pentoyl lactone

Pentoyl lactone clene

D-()-Pantolactone,(R)-()-α-Hydroxy-β,β-dimethyl-γ-butyrolactone, (R)-()-β,β-Dimethyl-α-hydroxy-γ-butyrolactone, (R)-()-Pantolactone, Pantoic acid γ-lactone

Pan-acid lactone

(-)-2-Hydroxy-3,3-diMethyl-γ-butyrolactone

(3R)-Dihydro-3-hydroxy-4,4-diMethyl-2(3H)-furanone

(3R)-Tetrahydro-3-hydroxy-4,4-diMethylfuran-2-one

(R)-(-)-Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone D-(-)-2-Hydroxy-3,3-dimethyl-gamma-butyrolactone D-(-)-Pantoyl Lactone

Dexpanthenol Lactone IMpurity

Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone

D-(-)-Pantolactone 99%

(R)-3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one

(R)-Pantolacton

Dexpanthenol Impurity 1

(3R)-3-hydroxy-4,4-dimethyloxolan-2-one

2,4-DIHYDROXY-3,3-DIMETHYLBUTYRIC ACID GAMMA-LACTONE

ALPHA-HYDROXY-BETA,BETA-DIMETHYL-GAMMA-BUTYROLACTONE

D-(-)-PANTOYL LACTONE

D-PANTOYL LACTONE

D-PANTOIC ACID G-LACTONE

(-)-D-PANTOLACTONE

D-(-)-PANTOLACTONE

D-PANTOLACTONE

D-ALPHA-HYDROXY-BETA,BETA-DIMETHYL-GAMMA-BUTYROLACTONE

D-1-HYDROXY-2,2-DIMETHYL-3-BUTYROLACTONE

D-(-)-2-HYDROXY-3,3-DIMETHYL-GAMMA-BUTYROLACTONE

D-(-)-DIHYDRO-3-HYDROXY-4,4-DIMETHYL-2(3H)-FURANONE

(R)-N-Pantolactone

(R)-Pantoyl lactone

alpha-Hydroxy-beta,beta-dimethyl-alpha-butyrolactone

D-MINUS-PANTOYLLACTONE

D-(-)-PANTOYL LACTONE 98+%

D-(-)-Pantanolactone

D-(-)-Pantolactone,99%